the most promising vaccine goes to human trial this week

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jimnbkk
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Re: the most primising vaccine goes to human trial this week

Post by jimnbkk »

40-60% efficacy is really not enough I think. I'm waiting for a successful vaccine to even consider travelling to Thailand again, but if governments are satisfied with that kind of efficacy, then I'll not go again. I'm more concerned with my interactions enroute than I am in Thailand, although if only 50/50 chance I'm not going to get sick, then think of all the other 50/50's I may interact with on such a trip! Not good odds I think.

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Re: the most primising vaccine goes to human trial this week

Post by gera »

One hundred scientists including 15 Nobel prize winners call for Human challenge trial. This includes the director of Jenner institute where the Oxford vaccine was developed. The bottom line: without real experiment on humans there is no way to know whether a vaccine works or not despite all this blurb about neutralizing antibodies and T-cells.

https://www.cnn.com/2020/07/16/health/v ... index.html

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Re: the most primising vaccine goes to human trial this week

Post by gera »

If you read this thread , you will see that I said that much earlier.
https://www.cnbc.com/2020/08/07/coronav ... great.html
By now I see Novavax vaccine as the most promising among those which are already in clinical (human) trials.

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Re: the most promising vaccine goes to human trial this week

Post by gera »

US started preparations for human challenge trial.
https://www.reuters.com/article/us-heal ... SKCN25A1EL
Uk made a deal with Novavax to purchase their vaccine.

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Re: the most promising vaccine goes to human trial this week

Post by gera »

Several scientifically confirmed cases of covid reinfection dash even further a hope for an efficient and long lasting vaccine (and frankly the so-called herd immunity). As I mentioned in one of my previous posts in this thread I think a good antiviral medication has a better chance to mitigate the infection. After all , there is no a good HIV vaccine but plenty of efficient antivirals. Can Merck drug be a game changer? I do not know but hope so...

https://www.bloomberg.com/news/articles ... -therapies

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Re: the most promising vaccine goes to human trial this week

Post by gera »

Trials of Oxford vaccine put on hold. Not sure how serious it is.
https://www.cnbc.com/2020/09/08/astraze ... -hold.html

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Re: the most promising vaccine goes to human trial this week

Post by gera »

is it breakthrough or just another biopharma company trying to boost their stock?
https://finance.yahoo.com/news/redhill- ... 00252.html

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Re: the most promising vaccine goes to human trial this week

Post by gera »

Kudos to UK. Despite the fact that the country obviously has much more limited resources than US , it shows true leadership in finding Covid remedies
( unlike US where FDA, CDC and others responsible for the action seem to only concern about how to protect their asses from possible liabilities while so many Americans die).
https://www.reuters.com/article/brief-u ... SFWN2GK0N8

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Re: the most promising vaccine goes to human trial this week

Post by windwalker »

There is an article in the NYTimes regarding the vaccine by Johnson and Johnson.

The headline is "Johnson & Johnson’s Vaccine Advances, Sparking Optimism in Race
Unlike some of its competitors, Johnson & Johnson’s vaccine does not need to be frozen and may require just one shot instead of two."

The article does point out that one company will not be able to produce enough vaccine for the entire world.

https://www.nytimes.com/2020/09/23/heal ... e=Homepage

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Re: the most promising vaccine goes to human trial this week

Post by Jun »

I was most encouraged by the prospect of challenge trials, until reading that they intend to start in January. Tomorrow would be my idea of a time to start, or better still, 3 months ago.

Open Orphan already have a secure 24 room facility for conducting challenge trials. With low demand for hotels, renting additional space should be easy.

I suppose all the pfaffing about is to calibrate a challenge dose & get it approved by over cautious regulators.

Despite being on the wrong side of 50, I'd volunteer, as long as it's a 100% vaccine 0% placebo trial.

[Slightly off topic, the organiser of 1daysooner.org is a fine looking young man]

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